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Recruitment of beta arrestins desensitizes both receptors, and this is followed by internalization, recycling, and inactivation of Gas

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Males and females were treated with 20 mM BSO (19176, Sigma-Aldrich) in the drinking water starting at 21 days of age, immediately after weaning

Specifically, a 40% CR has been shown to reduce the production of mitochondrial ROS and mitigate oxidative damage to mitochondrial DNA in rodent organs [163]

Aerobic production and utilization of lactate satisfy increased energy demands upon neuronal activation in hippocampal slices and provide neuroprotection against oxidative stress